دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Evaluation of immune status in testis and macrophage polarization associated with testicular damage in patients with nonobstructive azoospermia
Wenzhong Zheng,Shiqiang Zhang,Shaoqin Jiang,Zhangcheng Huang,Xiaobao Chen,Huan Guo,Mengqiang Li,Song Zheng
doi : 10.1111/aji.13481
Volume 86, Issue 5 e13481
Immune cells residing in the testicular interstitial space form the immunological microenvironment of the testis. They are assumed to play a role in maintaining testicular homeostasis and immune privilege. However, the immune status and related cell polarization in patients with nonobstructive azoospermia (NOA) remains poorly characterized. System evaluation of the testis immunological microenvironment in NOA patients may help to reveal the mechanisms of idiopathic azoospermia.
Increased cell-free fetal DNA release after apoptosis and sterile inflammation in human trophoblast cells
Nazanin Yeganeh Kazemi,Bohdana Fedyshyn,Isabel Yelsa,Yaroslav Fedyshyn,Rodrigo Ruano,Svetomir N. Markovic,Rana Chakraborty,Elizabeth Ann L. Enninga
doi : 10.1111/aji.13483
Volume 86, Issue 5 e13483
Cell-free fetal DNA (cffDNA) shed from the placenta can be detected in maternal blood and increases incrementally during gestation. Concentrations are further elevated with pregnancy complications. Specific activators of cffDNA release in such complications have not been identified. Here, we use trophoblast cells from early and term placenta to examine cffDNA release following apoptosis, infection, and sterile inflammatory stress.
Hsa_circ_0001326 regulates proliferation, migration, invasion, and EMT of HTR-8/SVneo cells via increasing IL16 expression
Yang Liu,Xuemei Ma,Yingying Liu
doi : 10.1111/aji.13484
Volume 86, Issue 5 e13484
Preeclampsia (PE) is a serious pregnancy complication. It has been shown that insufficient infiltration of extravillous trophoblasts (EVTs) is related to the pathogenesis of PE. Circular hsa_circ_0001326 (circ_0001326) has been uncovered to be upregulated in PE. However, the influence of circ_0001326 on the infiltration of trophoblasts is indistinct.
Circ_0011460 upregulates HTRA1 expression by sponging miR-762 to suppress HTR8/SVneo cell growth, migration, and invasion
Zhongyan Fan,Qiming Wang,Hui Deng
doi : 10.1111/aji.13485
Volume 86, Issue 5 e13485
Aberrant expression of circular RNAs (circRNAs) during placental development could affect fetal growth and contribute to preeclampsia (PE). Circ_0011460 was found to be differentially expressed in placental samples of PE. However, the exact function and mechanism of circ_0011460 in PE process remain largely undefined.
Effect of a high-calorie diet and constant light exposure on female reproduction, metabolism and immune inflammation: A comparative study of different mouse models
Lingshan Zhang,Yukai Liu,Mingqing Li,Xiaoyong Zhu,Yingli Shi
doi : 10.1111/aji.13479
Volume 86, Issue 5 e13479
Excess caloric intake and irregular circadian rhythm could severely impair female reproductive, metabolic, and immune function. However, the similarities and differences between their individual and combined effects and mechanisms have not been fully elucidated. Due to limitations and confounding factors in clinical research, we used these two kinds of unhealthy factors to intervene the mice singly or in combination to explore their effects on individuals.
Immune status of decidual macrophages is dependent on the CCL2/CCR2/JAK2 pathway during early pregnancy
Chun-Yan Wei,Ming-Qing Li,Xiao-Yong Zhu,Da-Jin Li
doi : 10.1111/aji.13480
Volume 86, Issue 5 e13480
Decidual macrophages (dM?) play an important role in the formation of maternal–fetal immune tolerance. However, factors that influence the immune status of dM? and the related potential mechanisms have not been elucidated to date.
Treatment following hysteroscopy and endometrial diagnostic biopsy increases the chance for live birth in women with chronic endometritis
Vera R. Mitter,Sheila Meier,Tilman T. Rau,Tessa Gillon,Michael D. Mueller,Marcel Zwahlen,Michael von Wolff,Alexandra S. Kohl Schwartz
doi : 10.1111/aji.13482
Volume 86, Issue 5 e13482
Repeated implantation failure and recurrent pregnancy loss are associated with chronic endometritis, a persistent endometrial inflammation. Its diagnosis and treatment may increase pregnancy and live birth rates. The aim of this study was to assess the effectiveness of endometrial diagnostic biopsy and subsequent antibiotic treatment in cases of chronic endometritis on reproductive outcomes over a long observation period.
Association between allergic or autoimmune diseases and incidence of endometriosis: A nested case-control study using a health insurance claims database
Erika Yoshii,Hayato Yamana,Sachiko Ono,Hiroki Matsui,Hideo Yasunaga
doi : 10.1111/aji.13486
Volume 86, Issue 5 e13486
Immune responses were reported to be associated with the pathogenesis of endometriosis. However, previous studies of an association between allergic or autoimmune diseases and endometriosis have reported inconsistent results. We investigated the association between allergic or autoimmune diseases and the incidence of endometriosis.
Elucidating the interaction between maternal physical activity and circulating myokines throughout gestation: A scoping review
Alexandra D. Goudreau,Catherine Everest,Taniya S. Nagpal,Jessica L. Puranda,Jayonta Bhattacharjee,Tarushika Vasanthan,Kristi B. Adamo
doi : 10.1111/aji.13488
Volume 86, Issue 5 e13488
Physical activity (PA) during pregnancy provides both maternal and fetal health benefits. It has been theorized that myokines, peptides secreted by contracting skeletal muscle, may play an important mechanistic role in facilitating the health benefits obtained from prenatal exercise. The objective of this review was to synthesize the current literature on the relationship between maternal PA and myokine response. A search strategy was developed using the terms pregnancy, PA, IL-6, IL-10, IL-13, and TNF-?. A systematic search was completed in July 2020, in Medline, SPORTDiscus, EMBASE, CENTRAL, and in November 2020 for unpublished dissertations (grey literature; Proquest). Both human- and animal-based studies of any design were included, while commentaries and editorial articles were excluded. Data were extracted by two independent reviewers and summarized narratively. Data were thematically summarized based on the myokine and whether findings were from human or animal studies. Ten studies were included in this review. Findings from studies that examined IL-6, IL-10, and TNF-? suggest a trimester-specific interaction between PA and myokine levels; no studies evaluated IL-13. Future research should investigate the PA-myokine relationship throughout all stages of gestation.
Intrauterine devices as an exposure risk for urinary tract infections: A scoping review
Claire T. Lo,Abin Abraham,Loren Lipworth,David M. Aronoff
doi : 10.1111/aji.13476
Volume 86, Issue 5 e13476
The intrauterine device (IUD) as a potential source of uro-gynecologic infection has raised concern for decades. While a causal link between IUD and pelvic inflammatory disease has been refuted, the relationship between IUDs and urinary tract infections (UTIs) remains incompletely understood.
Semen: A modulator of female genital tract inflammation and a vector for HIV-1 transmission
Janine Jewanraj,Sinaye Ngcapu,Lenine J. P. Liebenberg
doi : 10.1111/aji.13478
Volume 86, Issue 5 e13478
In order to establish productive infection in women, HIV must transverse the vaginal epithelium and gain access to local target cells. Genital inflammation contributes to the availability of HIV susceptible cells at the female genital mucosa and is associated with higher HIV transmission rates in women. Factors that contribute to genital inflammation may subsequently increase the risk of HIV infection in women. Semen is a highly immunomodulatory fluid containing several bioactive molecules with the potential to influence inflammation and immune activation at the female genital tract. In addition to its role as a vector for HIV transmission, semen induces profound mucosal changes to prime the female reproductive tract for conception. Still, most studies of mucosal immunity are conducted in the absence of semen or without considering its immune impact on the female genital tract. This review discusses the various mechanisms by which semen exposure may influence female genital inflammation and highlights the importance of routine screening for semen biomarkers in vaginal specimens to account for its impact on genital inflammation.
T lymphocytes and preeclampsia: The potential role of T-cell subsets and related MicroRNAs in the pathogenesis of preeclampsia
Mohammad Ali Zolfaghari,Reza Arefnezhad,Forough Parhizkar,Mohammad Saeid Hejazi,Farhad Motavalli Khiavi,Ata Mahmoodpoor,Mehdi Yousefi
doi : 10.1111/aji.13475
Volume 86, Issue 5 e13475
Innate and adaptive immune systems have a crucial role in initiating and progressing some pregnancy disorders such as preeclampsia (PE), which is one of the pregnancy-specific disorders that could result in neonatal and maternal morbidity and mortality. The dysregulation of the spiral artery and inadequate trophoblast invasion lead to PE symptoms through producing various inflammatory cytokines and anti-angiogenic factors from the placenta. T lymphocytes play a special role in the epithelium and stroma of the human endometrium. CD4+ T helper (Th) cells, Th1/Th2, and Th17/T regulatory (Treg) balance mainly contribute to the establishment of a pregnancy-favorable environment. This review examined the dysregulation of some cytokines produced from T cells, the dysregulation of the transcription factors of Th cells, the expression of chemokine receptors on T cells, as well as the effects of some factors including vitamin D on the activity of T cells, and finally, the dysregulation of various miRNAs related to T cells, which could cause PE.
The role of decidual natural killer cell-derived soluble factors in early pregnancy
Xueling Zhang,Yuye Li,Chunyu Huang,Su Liu,Xian Chen,Shuyi Yu,Lianghui Diao,Yong Zeng
doi : 10.1111/aji.13477
Volume 86, Issue 5 e13477
Decidual natural killer cells (dNK), the predominant decidual lymphocytes in early pregnancy, are primarily identified based on their CD56bright CD16? phenotype and play an important role in maintaining immune tolerance at the maternal–fetal interface. dNK dysfunction reportedly leads to pathological pregnancy. Indeed, various dNK-derived soluble factors are involved in a series of key processes related to pregnancy outcomes. In this review, we summarize the roles of these dNK-derived factors in immune tolerance and embryonic development to improve the current understanding regarding the physiological and pathological mechanisms that occur during pregnancy, while potentially informing the development of effective therapeutics.
Roles of ??T cells in pregnancy and pregnancy-related complications
Qian-Han Xu,Hong Liu,Li-Ling Wang,Qian Zhu,Yu-Jing Zhang,Kahindo P. Muyayalo,Ai-Hua Liao
doi : 10.1111/aji.13487
Volume 86, Issue 5 e13487
A successful pregnancy is a complex and unique process comprised of discrete events, including embryo implantation, placentation, and parturition. To maintain the balance between maternal-fetal immune tolerance and resistance to infections, the maternal immune system must have a high degree of stage-dependent plasticity throughout the period of pregnancy. Innate immunity is the frontline force for the establishment of early anti-infection and tolerance mechanisms in mammals. Belonging to the innate immune system, a subset of T cells called ??T cells (based on ??T cell receptors) are the main participants in immune surveillance and immune defense. Unlike traditional ??T cells, ??T cells are regarded as a bridge between innate immunity and acquired immunity. In this review, we summarize current knowledge on the functional plasticity of ??T cells during pregnancy. Furthermore, we discuss the roles of ??T cells in pathological pregnancies.
