European Heart Journal

Victor Aboyans, Rupert Bauersachs, Lucia Mazzolai, Marianne Brodmann, José F Rodriguez Palomares, Sebastian Debus, Jean-Philippe Collet, Heinz Drexel, Christine Espinola-Klein, Basil S Lewis, Marco Roffi, Dirk Sibbing, Henrik Sillesen, Eugenio Stabile, Oliver Schlager, Marco De Carlo

doi : 10.1093eurheartjehab390

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4013–4024

The aim of this collaborative document is to provide an update for clinicians on best antithrombotic strategies in patients with aortic andor peripheral arterial diseases. Antithrombotic therapy is a pillar of optimal medical treatment for these patients at very high cardiovascular risk. While the number of trials on antithrombotic therapies in patients with aortic or peripheral arterial diseases is substantially smaller than for those with coronary artery disease, recent evidence deserves to be incorporated into clinical practice. In the absence of specific indications for chronic oral anticoagulation due to concomitant cardiovascular disease, a single antiplatelet agent is the basis for long-term antithrombotic treatment in patients with aortic or peripheral arterial diseases. Its association with another antiplatelet agent or low-dose anticoagulants will be discussed, based on patient’s ischaemic and bleeding risk as well therapeutic paths (e.g. endovascular therapy). This consensus document aims to provide a guidance for antithrombotic therapy according to arterial disease localizations and clinical presentation. However, it cannot substitute multidisciplinary team discussions, which are particularly important in patients with uncertain ischaemicbleeding balance. Importantly, since this balance evolves over time in an individual patient, a regular reassessment of the antithrombotic therapy is of paramount importance.

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Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial

Himawan Fernando, Thy Duong, Kevin Huynh, Jonathan Noonan, James Shaw, Stephen J Duffy, Ziad Nehme, Karen Smith, Paul S Myles, Peter J Meikle, Karlheinz Peter, Dion Stub

doi : 10.1093eurheartjehab557

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4025–4036

We assessed the impact of intravenous fentanyl and lignocaine on the pharmacokinetics and pharmacodynamics of ticagrelor in patients with unstable angina and non-ST-elevation myocardial infarction and their procedural analgesic efficacy and safety.

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Non-opioid analgesics in patients undergoing percutaneous coronary intervention: hype or hope?

Mattia Galli, Dominick J Angiolillo

doi : 10.1093eurheartjehab595

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4037–4039

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Low-dose rivaroxaban plus aspirin in older patients with peripheral artery disease undergoing acute limb revascularization: insights from the VOYAGER PAD trial

Mori J Krantz, Sebastian E Debus, Judith Hsia, Manesh R Patel, Sonia S Anand, Mark R Nehler, Connie N Hess, Warren H Capell, Taylor Bracken, Michael Szarek, Lajos Mátyás, Dainis K Krievins, Patrice Nault, Stefan Stefanov, Lloyd P Haskell, Scott D Berkowitz, Eva Muehlhofer, William R Hiatt, Rupert M Bauersachs, Marc P Bonaca

doi : 10.1093eurheartjehab408

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4040–4048

In this secondary analysis of the VOYAGER trial, rivaroxaban 2.5 mg twiceday plus aspirin 100 mgday was assessed in older adults. Advanced age is associated with elevated bleeding risk and unfavourable net benefit for dual antiplatelet therapy in chronic coronary artery disease. The risk–benefit of low-dose rivaroxaban in patients ?75 years with peripheral artery disease (PAD) after lower extremity revascularization (LER) has not been described.

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Low-dose rivaroxaban plus aspirin for elderly patients with symptomatic peripheral artery disease: is it worth the bleeding risk?

Juqian Zhang, S R Vallabhaneni, Gregory Y H Lip

doi : 10.1093eurheartjehab602

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4049–4052

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Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score

Jimin Hwang, Seung Hyun Park, Seung Won Lee, Se Bee Lee, Min Ho Lee, Gwang Hun Jeong, Min Seo Kim, Jong Yeob Kim, Ai Koyanagi, Louis Jacob, Se Yong Jung, Jaewoo Song, Dong Keon Yon, Jae Il Shin, Lee Smith

doi : 10.1093eurheartjehab592

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4053–4063

The clinical manifestation and outcomes of thrombosis with thrombocytopenia syndrome (TTS) after adenoviral COVID-19 vaccine administration are largely unknown due to the rare nature of the disease. We aimed to analyse the clinical presentation, treatment modalities, outcomes, and prognostic factors of adenoviral TTS, as well as identify predictors for mortality.

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Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia

Sverre Holm, Hassen Kared, Annika E Michelsen, Xiang Yi Kong, Tuva B Dahl, Nina H Schultz, Tuula A Nyman, Cathrine Fladeby, Ingebjørg Seljeflot, Thor Ueland, Maria Stensland, Siri Mjaaland, Guro Løvik Goll, Lise Sofie Nissen-Meyer, Pål Aukrust, Karolina Skagen, Ida Gregersen, Mona Skjelland, Pål A Holme, Ludvig A Munthe, Bente Halvorsen

doi : 10.1093eurheartjehab506

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4064–4072

We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10?days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). We aimed to investigate the pathogenic immunological responses operating in these patients.

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Thromboinflammatory findings and clinical predictors of mortality in vaccine-induced immune thrombotic thrombocytopenia

Jean M Connors

doi : 10.1093eurheartjehab585

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4073–4076

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Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis

Julia Hinterdobler, , Simin Schott, Hong Jin, Almut Meesmann, Anna-Lena Steinsiek, Anna-Sophia Zimmermann, Jana Wobst, Philipp Müller, Carina Mauersberger, Baiba Vilne, Alexandra Baecklund, Chien-Sin Chen, Aldo Moggio, Quinte Braster, Michael Molitor, Markus Krane, Wolfgang E Kempf, Karl-Heinz Ladwig, Michael Hristov, Maarten Hulsmans, Ingo Hilgendorf, Christian Weber, Philip Wenzel, Christoph Scheiermann, Lars Maegdefessel, Oliver Soehnlein, Peter Libby, Matthias Nahrendorf, Heribert Schunkert, Thorsten Kessler, Hendrik B Sager

doi : 10.1093eurheartjehab371

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4077–4088

Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear.

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The endothelium is a key player in the vascular response to acute mental stress

Jaskanwal Deep Singh Sara, Lliach O Lerman, Amir Lerman

doi : 10.1093eurheartjehab510

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4089–4091

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The neutrophil–lymphocyte ratio and incident atherosclerotic events: the impact of racial differences?

Philippe Giral, Elisa Deflorenne, Anatol Kontush

doi : 10.1093eurheartjehab256

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Page 4092

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Thrombolysis for COVID-19-associated bioprosthetic mitral valve thrombosis with shock

Shravya Vinnakota, Jacob C Jentzer, Sushil A Luis

doi : 10.1093eurheartjehab333

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Page 4093

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Fishing an anemone in the brain: embolized cardiac fibroelastoma revealed after stroke thrombectomy

Aurora Semerano, Guillaume Saliou, Francesca Sanvito, Angela Genchi, Giorgia Serena Gullotta, Patrik Michel, Massimo Filippi, Gianvito Martino, Davide Strambo, Marco Bacigaluppi

doi : 10.1093eurheartjehab019

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Pages 4094–4095

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Erratum to: CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure

doi : 10.1093eurheartjehab594

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Page 4036

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Corrigendum to: The importance of achieving sex- and gender-based equity in clinical trials: a call to action

doi : 10.1093eurheartjehab583

European Heart Journal, Volume 42, Issue 39, 14 October 2021, Page 4048

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