Journal of the American College of Cardiology




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doi : 10.1016/S0735-1097(21)05660-6

Volume 78, Issue 8, 24 August 2021, Page e43

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Contents

doi : 10.1016/S0735-1097(21)05781-8

Volume 78, Issue 8, 24 August 2021, Pages e45-e47

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De-Escalation of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndromes

SatoshiShojiMD, PhDa?ToshikiKunoMD, PhDb?TomohiroFujisakiMDcHisatoTakagiMD, PhDdAlexandrosBriasoulisMD, PhDePierreDeharoMDfghThomasCuissetMD, PhDfghAzeemLatibMDiShunKohsakaMD, PhDa

doi : 10.1016/j.jacc.2021.06.012

Volume 78, Issue 8, 24 August 2021, Pages 763-777

Balancing the effects of dual antiplatelet therapy (DAPT) in the era of potent P2Y12 inhibitors has become a cornerstone of acute coronary syndrome (ACS) management. Recent randomized controlled trials (RCTs) have investigated DAPT de-escalation to decrease the risk of bleeding outcomes.

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De-Escalation of DAPT After ACS: Escalating the Odds of Getting It Right?

Kwan S.LeeMDArkaChatterjeeMDDeepakAcharyaMD

doi : 10.1016/j.jacc.2021.06.030

Volume 78, Issue 8, 24 August 2021, Pages 778-780

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A Biomarker Model to Distinguish Types of Myocardial Infarction and Injury

Johannes T.NeumannMD, MCRabcJessicaWeimannMScaNils A.S?rensenMDabTau S.HartikainenMDaPaul M.HallerMD, PhDabJonasLehmacherMDaCelineBrocksaSophiaTenhaeffaMahirKarakasMD, PhDabThomasRennéPhDdStefanBlankenbergMDabTanjaZellerPhDabDirkWestermannMDab

doi : 10.1016/j.jacc.2021.06.027

Volume 78, Issue 8, 24 August 2021, Pages 781-790

Discrimination among patients with type 1 myocardial infarction (T1MI), type 2 myocardial infarction (T2MI), and myocardial injury is difficult.

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Untangling Myocardial Injury: Moving From Consequence to Cause?

James L.JanuzziJr.MDabCian P.McCarthyMB, BCh, BAOa

doi : 10.1016/j.jacc.2021.06.026

Volume 78, Issue 8, 24 August 2021, Pages 791-793

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Dissemination of Transcatheter Aortic Valve Replacement in the United States

Javier A.ValleMD, MSCSabcZhuokaiLiPhDdAndrzej S.KosinskiPhDdAdam J.NelsonMBBS, PhDdSreekanthVemulapalliMDdeJosephClevelandMDbDavidFullertonMDbJohn C.MessengerMDbJessica Y.RoveMDbRory S.BrickerMDbSteven M.BradleyMD, MPHfFrederick A.MasoudiMD, MSPHbRobert W.YehMD, MSc, MBAgEhrin J.ArmstrongMD, MScabStephen W.WaldoMDabJohn D.CarrollMDb

doi : 10.1016/j.jacc.2021.06.028

Volume 78, Issue 8, 24 August 2021, Pages 794-806

Societal guidelines and payor coverage decisions for transcatheter aortic valve replacement (TAVR) attempt to strike a balance between providing access and maintaining quality. The extent to which dissemination of TAVR has achieved these ideals remains unknown.

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Rational Dispersion of TAVR: Failed Expectations and Unintended Consequences?

David R.HolmesJr.MDaD. CraigMillerMDb

doi : 10.1016/j.jacc.2021.07.008

Volume 78, Issue 8, 24 August 2021, Pages 807-810

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The Characteristics and Outcomes of Native Aortic Valve Thrombosis: A Systematic Review

WissamAlajajiMDaJohn M.HornickMDaElianeMalekMDbAllan L.KleinMDc

doi : 10.1016/j.jacc.2021.06.023

Volume 78, Issue 8, 24 August 2021, Pages 811-824

There is a lack of knowledge in the current medical literature about native aortic valve thrombosis.

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Aortic Valve Thrombosis: Be Prepared for the Unusual?

Jose Luis ZamoranoG?mezMD, PhDAriana Gonz?lezG?mezMD

doi : 10.1016/j.jacc.2021.06.025

Volume 78, Issue 8, 24 August 2021, Pages 825-826

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Primary and Secondary Outcome Reporting in Randomized Trials: JACC State-of-the-Art Review

Stuart J.PocockPhDabXavierRosselloPhDabRuthOwenMScaTim J.CollierMScaGregg W.StoneMDcFrank W.RockholdPhDd

doi : 10.1016/j.jacc.2021.06.024

Volume 78, Issue 8, 24 August 2021, Pages 827-839

Consensus as to best practices for the selection, reporting, and interpretation of primary and secondary outcomes of randomized controlled trials is lacking. We reviewed the strategies adopted in publications of randomized controlled trials (RCTs) for the analysis, presentation, and interpretation of efficacy outcomes from a survey of all cardiovascular RCTs published in the New England Journal of Medicine, Lancet, and the Journal of the American Medical Association during 2019. We focus on the choice of primary outcomes, the variety of approaches to selecting secondary outcomes, the options sometimes used to control type I error, and the common practice to not correct for multiple testing in reporting secondary outcomes. We comment on current practice across journals in the reporting of P values and also how conclusions in trial reports frequently adhere to an undue reliance on P < 0.05 as a basis for positive claims of treatment efficacy. We conclude with recommendations for how future RCT reports could best select, report, and interpret their findings on primary and secondary outcomes.

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Global Chronic Total Occlusion Crossing Algorithm: JACC State-of-the-Art Review

Eugene B.WuMDaEmmanouil S.BrilakisMD, PhDbKambisMashayekhiMDcEtsuoTsuchikaneMD, PhDdKhaldoonAlaswadMDeMarioArayaMDfAlexandreAvranMDgLorenzoAzzaliniMD, MSc, PhDhAvtandil M.BabunashviliMDiBaktashBayaniMDjMichaelBehnesMDkRavinayBhindiMDlNicolasBoudouMDmMarouaneBoukhrisMDnNenad Z.BozinovicMDoLeszekBryniarskiMDpAlexanderBufeMDqChristopher E.BullerMDrsM. NicholasBurkeMDbAchimButtnerMDsPedroCardosoMDtMauroCarlinoMDuJi-YanChenMDvEvald HoejChristiansenMDwAntonioColomboMDxKevinCroceMD, PhDyFelix Damasde los SantosMD, METzTonyde MartiniMDaaJosephDensMD, PhDbbCarlodi MarioMDccKefeiDouMDddMohanedEgredMDeeBasemElbarouniMDffAhmed M.ElGuindyMDggJavierEscanedMDhhSergeyFurkaloMDiiAndreaGagnorMDjjAlfredo R.GalassiMDkkRobertoGarboMDllGabrieleGaspariniMDmmJunboGeMDnnLeiGeMDnnPravin KumarGoelMDooOmerGoktekinMDppNievesGonzaloMDqqLucaGranciniMDrrAllisonHallMDssFranklin LeonardoHanna QuesadaMDttColmHanrattyMDuuStefanHarbMDvvScott A.HardingMDwwRajaHatemMDxxJose P.S.HenriquesMDyyDavidHildick-SmithMDzzJonathan M.HillMDaaaAngelaHoyeMDbbbWissamJaberMDcccFarouc A.JafferMD, PhDdddYangsooJangMDeeeRistoJussilaMDfffArtisKalninsMDgggArunKalyanasundaramMD, MPHhhhDavid E.KandzariMDiiiHsien-LiKaoMDjjjDimitriKarmpaliotisMD, PhDkkkHussien HeshmatKassemMD, PhDlllJaikirshanKhatriMDmmmPaulKnaapenMDnnnRanKornowskiMDoooOlegKrestyaninovMDpppA.V. GaneshKumarMDqqqPablo ManuelLamelasMD, MScrrrSeung-WhanLeeMDsssThierryLefevreMDtttRaymondLeungMDuuuYuLiMDvvvYueLiMDwwwSoo-TeikLimMDxxxSidneyLoMDyyyWilliamLombardiMDzzzAnbukarasiMaranMDaaaaMargaretMcEntegartMD, PhDbbbbJeffreyMosesMDccccMuhammadMunawarMDddddAndresNavarroMDeeeeHung M.NgoMD, PhDffffWilliamNicholsonMDggggAnjaOksnesMDhhhhGoran K.OlivecronaMD, PhDiiiiLucioPadillaMDjjjjMitulPatelMDkkkkAshishPershadMDllllMarinPostuMDmmmmJieQianMDnnnnAlexandreQuadrosMDooooNidal AbiRafehMDppppTrulsR?munddalMD, PhDqqqqVithala SuryaPrakasa RaoMDrrrrNicolausReifartMD, PhDssssRobert F.RileyMDttttStephaneRinfretMDuuuuMeruzhanSaghatelyanMDvvvvGeorgeSianosMD, PhDwwwwElliotSmithMDxxxxAnthonySpaedyMDyyyyJamesSprattMDzzzzGreggStoneMDaaaaaJulian W.StrangeMDbbbbbKhalid O.TammamMD, PhDcccccCraig A.ThompsonMDdddddAurelTomaMDeeeeeJennifer A.TremmelMD, MSfffffRicardo SantiagoTrinidadMDgggggImreUngiMD, PhDhhhhhMinhVoMDiiiiiVu HoangVuMDjjjjjSimonWalshMDuuGeraldWernerMDkkkkkJaroslawWojcikMDlllllJasonWollmuthMDmmmmmBoXuMDnnnnnMasahisaYamaneMDoooooLuiz F.YbarraMDpppppRobert W.YehMDqqqqqQiZhangMDrrrrr

doi : 10.1016/j.jacc.2021.05.055

Volume 78, Issue 8, 24 August 2021, Pages 840-853

The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel quality using the retrograde approach and bifurcation at the distal cap by use of a dual-lumen catheter and intravascular ultrasound; 5) feasibility of retrograde crossing through grafts and septal and epicardial collateral vessels; 6) antegrade wiring strategies; 7) retrograde approach; 8) changing strategy when failing to achieve progress; 9) considering performing an investment procedure if crossing attempts fail; and 10) stopping when reaching high radiation or contrast dose or in case of long procedural time, occurrence of a serious complication, operator and patient fatigue, or lack of expertise or equipment. This algorithm can improve outcomes and expand discussion, research, and collaboration.

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Age-Specific Racial Disparities in Mortality From Infancy to Older Adulthood: A Life Course Perspective

Kiarri N.KershawPhDJaneRaffertyMALucia C.PetitoPhDSadiya S.KhanMD

doi : 10.1016/j.jacc.2021.06.029

Volume 78, Issue 8, 24 August 2021, Pages 854-855

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The Importance of Objective Nutritional Indexes in Heart Failure Patients

TakenoriIkomaMDHidekiSaitoMDToshiakiOkaMD, PhDYuichiroMaekawaMD, PhD

doi : 10.1016/j.jacc.2021.06.013

Volume 78, Issue 8, 24 August 2021, Pages 855-856

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Reply: The Importance of Objective Nutritional Indexes in Heart Failure Patients

LaraHersbergerMDZenoStangaMDPhilippSchuetzMD, MPH

doi : 10.1016/j.jacc.2021.06.015

Volume 78, Issue 8, 24 August 2021, Pages 856-857

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