دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Triaging abnormal cervical cancer screening tests using p16INK4a detection by ELISA on fresh cervical samples
Shuk On Annie Leung,Sarah Feldman,Rajeshwari Kalyanaraman,Vignesh Shanmugam,Michael J. Worley,Ross S. Berkowitz,Neil S. Horowitz,Colleen M. Feltmate,Michael G. Muto,Larissa J. Lee,Martin T. King,Jon I. Einarsson,Mobolaji O. Ajao,Kevin M. Elias
doi : 10.1111/aji.13394
Volume 86, Issue 1 e13394
Cervical cancer screening strategies in the United States include cotesting (human papillomavirus (HPV) with cytology), primary HPV with genotyping and reflex cytology, and cytology alone. An ongoing challenge is the appropriate triage of patients to colposcopy to those at highest risk. We investigated whether incorporation of p16INK4a immunodetection by enzyme-linked immunosorbent assay (ELISA) on fresh cervical samples obtained at the time of screening could improve appropriate referral to colposcopy.
Transcriptomics-determined chemokine-cytokine pathway presents a common pathogenic mechanism in pregnancy loss and spontaneous preterm birth
Peirong Wang,Jing Pan,Xiujuan Tian,Xiaoyan Dong,Weina Ju,Yong Wang,Nanbert Zhong
doi : 10.1111/aji.13398
Volume 86, Issue 1 e13398
Various etiological factors, such as infection and inflammation, may induce the adverse outcomes of pregnancy of miscarriage, stillbirth, or preterm birth. The pathogenic mechanisms associated with these adverse pregnancies are yet unclear. We hypothesized that a common pathogenic mechanism may underlie variant adverse outcomes of pregnancy, which are induced by genetic-environmental factors. The specific objective of the current study is to uncover the common molecular mechanism(s) by identifying the specific transcripts that are present in variant subtypes of pregnancy loss and preterm birth.
Maternal celiac disease and the risk for long-term infectious morbidity of the offspring
Naim Abu-Freha,Tamar Wainstock,Aerin Philip,Eyal Sheiner
doi : 10.1111/aji.13399
Volume 86, Issue 1 e13399
Celiac disease is an autoimmune disease, patients with celiac have increased risk for infections, and offspring of celiac mothers have increased morbidity. The aim of the study was to assess long-term infectious morbidity among offspring of pregnant women with celiac disease.
Receptor-interacting protein kinase 2 contributes to host innate immune responses against Fusobacterium nucleatum in macrophages and decidual stromal cells
Ji-Yeon Park,Tae-Sung Lee,Eui Jeong Noh,Ah-Ra Jang,Jae-Hun Ahn,Dong-Yeon Kim,Do-Hyeon Jung,Eun-Jung Song,Yeon-Ji Lee,Yun-Ji Lee,Sung Ki Lee,Jong-Hwan Park
doi : 10.1111/aji.13403
Volume 86, Issue 1 e13403
Chorioamnionitis is caused by a bacterial infection that ascends from the vagina and can cause adverse pregnancy outcomes (APOs). Fusobacterium nucleatum (F. nucleatum) is a periodontal pathogen associated with the occurrence of APOs. In this study, we evaluated whether receptor-interacting protein kinase 2 (Ripk2), an adaptor protein of the cytosolic receptors nucleotide-binding oligomerization domain (NOD)1 and NOD2, in macrophages and human decidual stromal cells (hDSCs) contributes to immune responses against F. nucleatum.
Evidence for anti-inflammatory effects of firocoxib administered to mares with experimentally induced placentitis
Margo L. Macpherson,Steeve Giguère,Malgorzata A. Pozor,Chelsie A. Burden,Londa J. Berghaus,Roy D. Berghaus,Jennifer C. Varner,Justin T. Hayna,Susanne M. Benson,Sarah A. Randell,Sara K. Lyle,Audrey A. Kelleman,Kelsey A. Hart,Martha F. Mallicote,David W. Horohov
doi : 10.1111/aji.13396
Volume 86, Issue 1 e13396
Minimal evidence exists supporting therapeutic selections for equine placentitis. The goal of this study was to characterize the anti-inflammatory effects of firocoxib when administered to mares with placentitis.
DNA damage contributes to transcriptional and immunological dysregulation of testicular cells during Chlamydia infection
Emily R. Bryan,Roberto A. Barrero,Eddie Cheung,Jacob A. D. Tickner,Logan K. Trim,Derek Richard,Eileen A. McLaughlin,Kenneth W. Beagley,Alison J. Carey
doi : 10.1111/aji.13400
Volume 86, Issue 1 e13400
Chlamydia is the most commonly reported sexually transmitted bacterial infection, with 127 million notifications worldwide each year. Both males and females are susceptible to the pathological impacts on fertility that Chlamydia infections can induce. However, male chlamydial infections, particularly within the upper reproductive tract, including the testis, are not well characterized. In this study, using mouse testicular cell lines, we examined the impact of infection on testicular cell lineage transcriptomes and potential mechanisms for this impact. The somatic cell lineages exhibited significantly fragmented genomes during infection. Likely resulting from this, each of the Leydig, Sertoli and germ cell lineages experienced extensive transcriptional dysregulation, leading to significant changes in cellular biological pathways, including interferon and germ-Sertoli cell signalling. The cell lineages, as well as isolated spermatozoa from infected mice, also contained globally hypomethylated DNA. Cumulatively, the DNA damage and epigenetic-mediated transcriptional dysregulation observed within testicular cells during chlamydial infection could result in the production of spermatozoa with abnormal epigenomes, resulting in previously observed subfertility in infected animals and congenital defects in their offspring.
Transient systemic inflammation in adult male mice results in underweight progeny
Sushama Rokade,Manoj Upadhya,Dattatray S. Bhat,Nishikant Subhedar,Chittaranjan S. Yajnik,Aurnab Ghose,Satyajit Rath,Vineeta Bal
doi : 10.1111/aji.13401
Volume 86, Issue 1 e13401
While the testes represent an immune-privileged organ, there is evidence that systemic inflammation is accompanied by local inflammatory responses. We therefore examined whether transient systemic inflammation caused any inflammatory and functional consequences in murine testes.
Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women
Amy L Shafrir,Marissa C. Palmor,Jessica Fourquet,Amy D. DiVasta,Leslie V. Farland,Allison F. Vitonis,Holly R Harris,Marc R. Laufer,Daniel W. Cramer,Kathryn L. Terry,Stacey A. Missmer
doi : 10.1111/aji.13404
Volume 86, Issue 1 e13404
Associations between immune dysfunction conditions (eg, systemic lupus erythematous, rheumatoid arthritis) and endometriosis have been observed in adult women, but not assessed among a younger population. We investigated the association between immune-mediated conditions and endometriosis among young women.
Effect of injectable progestin-only contraceptives, depot medroxyprogesterone acetate and norethisterone enanthate, on cytokine production during T-cell activation
Allen T. Matubu,Sharon L. Hillier,Leslie A. Meyn,Kevin A. Stoner,Felix Mhlanga,Mike Mbizvo,Aaron Maramba,Zvavahera M. Chirenje,Sharon L. Achilles
doi : 10.1111/aji.13405
Volume 86, Issue 1 e13405
There is paucity of human data about the effects of depot medroxyprogesterone (DMPA) and norethisterone enanthate (Net-En) use on systemic immune function, which may have implications for reproductive tract infection susceptibility and transmissibility. We sought to evaluate the impact of injectable contraceptive use on T-cell responsiveness using T cells exposed in vivo and tested ex vivo.
Melatonin for the prevention of fetal injury associated with intrauterine inflammation
Jang Mee Kim,Seung-Yun Lee,Ji Yeon Lee
doi : 10.1111/aji.13402
Volume 86, Issue 1 e13402
Intrauterine inflammation is shown to be associated with preterm birth, fetal inflammatory response syndrome, and other pregnancy-related comorbidities such as central nervous system diseases including cerebral palsy and periventricular leukomalacia, pulmonary diseases such as bronchopulmonary dysplasia and respiratory distress syndrome, and necrotizing enterocolitis, to name a few. Many animal studies on intrauterine inflammation demonstrate that ascending infection of reproductive organs or the production of proinflammatory cytokines by some stimuli in utero results in such manifestations. Melatonin, known for its primary function in maintaining circadian rhythm, is now recognized as one of the most potent antioxidant and anti-inflammatory drugs. In some studies, melatonin injection in pregnant animals with intrauterine inflammation significantly reduced the number of preterm births, the severity of structural disintegration of the fetal lungs observed in bronchopulmonary dysplasia, and perinatal brain injuries with improvement in neuromotor function. These implicated benefits of melatonin in pregnant women with intrauterine inflammation seem promising in many research studies, strongly supporting the hypothesis that melatonin has antioxidative and anti-inflammatory properties that can potentially be taken by pregnant women who are at risk of having intrauterine inflammation. In this review, the potential of melatonin for improving outcomes of the pregnancies with intrauterine inflammation will be discussed.
