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Maximum sensitivity of procedures for detecting minimal residual disease in hematologic malignancies

Maximum sensitivity of procedures for detecting minimal residual disease in hematologic malignancies
Technique and criterion Blasts per 100,000 nucleated cells*
Standard microscopy ("complete remission") 5,000
Karyotype analysis (20 mitotic figures) 5,000
Microscopy, expert 1,000
Immunophenotyping: multi-parameter flow cytometry 10
Colony growth 1
Polymerase chain reaction 0.1
Detection_min_residual_dise.htm
The numbers given here are the maximum sensitivities reported for each procedure. Note that certain techniques may not be applicable in every patient (see text).
* The lower level of minimal residual disease predictive of ultimate relapse (ie, the level at which relapse is more likely than not) is currently unknown, and is likely to differ among the various malignant disorders, between children and adults, and among the techniques which are employed (see text).
Graphic 70804 Version 3.0

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