Agent | Bilirubin | Aminotransferases | Percent dose administered | Reference |
Bendamustine | ≥1.5 × ULN | ≥2.5 × ULN | Not recommended | |
Bortezomib | >1.5 × ULN | Reduce starting dose to 0.7 mg/m2 | ||
Cabazitaxel | >ULN | AST/ALT ≥1.5 × ULN | 0% | |
Carfilzomib | Refer to text | |||
Cyclophosphamide | 3.1 to 5 mg/dL | AST ≥180 IU/L | 75% | [1] |
>5 mg/dL | 0% | |||
Cytarabine | Any | 50%; subsequent increase by monitoring toxicity | [1] | |
Dactinomycin | Any | 50%; subsequent increase by monitoring toxicity | ||
Daunorubicin | 1.2 to 3 mg/dL | 75% | [1] | |
3 to 5 mg/dL | 50% | |||
>5 mg/dL | 0% | |||
Docetaxel | Refer to text | |||
Doxorubicin | 1.2 to 3 mg/dL | ALT or AST >3 × ULN | 50% | [1] |
3 to 5 mg/dL | 25% | |||
>5 mg/dL | 0% | |||
Epirubicin | 1.2 to 3 mg/dL | 2 to 4 × ULN | 75% | [1] |
>3 mg/dL | >4 × ULN | 50% | ||
Eribulin | Refer to text | |||
Etoposide | 1.5 to 3 mg/dL | AST >3 × ULN | 50% | [1] |
Fluorouracil | >5 mg/dL | 0% | [1] | |
Gemcitabine | >1.6 mg/dL | 80%¶ | ||
Ifosfamide | >3 mg/dL | 25% | [1,2] | |
Irinotecan | 1.5 to 3 mg/dL | 75% | [1] | |
Ixabepilone monotherapy | ≤1 × ULN | AST and ALT ≤2.5 × ULN | Initial dose (40 mg/m2) | |
≤1 × ULN | AST and ALT ≤10 × ULN | Initial dose (32 mg/m2) | ||
>1.5 to ≤3 × ULN | AST and ALT ≤10 × ULN | Initial dose (20 to 30 mg/m2) | ||
>3 × ULN | >10 × ULN | Not recommended | ||
Ixabepilone plus capecitabine | ≥2.5 × ULN | Above ULN | Not recommended | |
Ixazomib | >1.5 × ULN | Reduce starting dose to 3 mg | ||
Paclitaxel | Refer to text | |||
Panobinostat | ≥1 × ULN | AST >1 × ULN | 75% | |
>1 to 1.5 × ULN | Any | 75% | ||
>1.5 to 3 × ULN | Any | 50% | ||
>3 × ULN | Not recommended | |||
Pomalidomide | Refer to text | |||
Procarbazine | >5 mg/dL | ALT or AST >3 × ULN | 0% | [1] |
Trabectedin | Refer to text | |||
Vincristine, vinblastine | >3 mg/dL | 50% | [3] | |
Vinorelbine | 2.1 to 3 mg/dL | 50% | [1] | |
>3 mg/dL | 25% | |||
Vorinostat | >1 to 3 × ULN | Reduce initial doseΔ | ||
>3 × ULN | Not recommended |
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