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Thyroid physiology in the fetus and newborn

Thyroid physiology in the fetus and newborn
Normal patterns of change for TSH, total T4, and total T3 are depicted for the fetus (beginning at 12 weeks gestation) and continuing for the first 4 weeks of life in the newborn.
NOTE: To convert T3 in ng/dL to nmol/L, multiply by 0.01536. To convert T4 in mcg/dL to nmol/L, multiply by 12.87.
TSH: thyroid-stimulating hormone; T3: triiodothyronine; T4: thyroxine.
Data from:
  1. Thorpe-Beeston JG, Nicolaides KH, Felton CB, et al. Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. N Engl J Med 1991; 324:532.
  2. Fisher DA. Thyroid physiology in the perinatal period and during childhood. In: Werner's and Ingbar's The Thyroid, Braverman LE, Utiger RD (Eds), Lippincott-Raven, Philadelphia, 1996. p.974.
  3. Williams FL, Simpson J, Delahunty C, et al. Developmental trends in cord and postpartum serum thyroid hormones in preterm infants. J Clin Endocrinol Metab 2004; 89:5314.
Graphic 68673 Version 4.0

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