Types of cutaneous vasculitis^[1]

	PAN	c-PAN	NV	GP (WG)	EGP (CSS)	MPA	CV	RV	IgA (HSP)	UV	CSVV
Vessel size	Medium	Medium	Medium	Medium and small	Medium and small	Medium and small	Medium and small	Medium and small	Small	Small	Small
Cutaneous findings	Nodules, ulcers, livedo racemosa, infarcts	Nodules, ulcers, livedo racemosa	Nodules, ulcers Lower extremity edema	Nodules, ulcers, livedo racemosa, infarcts, palpable purpura Saddle nose deformity Strawberry gums	Nodules, ulcers, livedo racemosa, infarcts, palpable purpura	Nodules, ulcers, livedo racemosa, infarcts, palpable purpura	Nodules, ulcers, livedo racemosa, infarcts, palpable purpura	Nodules, ulcers, livedo racemosa, infarcts, palpable purpura	Urticarial papules, purpura, petechiae	Urticarial papules, purpura, petechiae	Urticarial papules, purpura, petechiae
Systemic symptoms/involvement	Weight loss, myalgia, fatigue, neuropathy, hypertension Decreased renal perfusion	Weight loss, myalgia, fatigue, neuropathy	Tuberculosis	Weight loss, myalgia, fatigue, neuropathy Glomerulonephritis Necrotizing granulomatous inflammation of respiratory tract	Weight loss, myalgia, fatigue, neuropathy Allergies Asthma Heart and GI involvement (especially if p-ANCA -) Glomerulonephritis and neuropathy (especially if p-ANCA +)	Weight loss, myalgia, fatigue, neuropathy Alveolar hemorrhage Glomerulonephritis	Weight loss, myalgia, fatigue, peripheral neuropathy Membranoproliferative glomerulonephritis	Weight loss, myalgia, fatigue, neuropathy Deforming arthritis	Arthritis, abdominal pain, renal involvement	Fever, angioedema, arthralgias, abdominal pain, Raynaud phenomenon, uveitis, obstructive lung disease	Fatigue
Helpful lab/study findings	Negative ANCAs	Negative ANCAs	PPD CXR	+c-ANCA +PR3	+p-ANCA +MPO Eosinophilia	+p-ANCA No eosinophilia	Hepatitis C+ plus cryoglobulins	High titer rheumatoid factor	Urinalysis looking for renal involvement	Low complement levels	No systemic involvement
DIF	Negative	Negative	Negative	Negative	Negative	Negative	+IgM	+IgM	IgA	IgG, C3, fibrin, can also be seen along DEJ	C3, IgM, IgA, IgG

PAN: polyarteritis nodosa; c-PAN: cutaneous polyarteritis nodosa; NV: nodular vasculitis; GP (WG): granulomatosis with polyangiitis (Wegener's granulomatosis); EGP (CSS): eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome); MPA: microscopic polyangiitis; CV: cryoglobulinemic vasculitis; RV: rheumatoid arthritis; IgA (HSP): IgA vasculitis (Henoch-Schönlein purpura); UV: urticarial vasculitis; CSVV: cutaneous small vessel vasculitis; GI: gastrointestinal; p-ANCA: perinuclear antineutrophil cytoplasmic antibody; ANCA: antineutrophil cytoplasmic antibody; PPD: purified protein derivative; CXR: chest radiograph; PR3: proteinase-3; MPO: myeloperoxidase; DIF: direct immunofluorescence; IgM: immunoglobulin M; IgA: immunoglobulin A; IgG: immunoglobulin G; DEJ: dermal-epidermal junction.

Reference:

Carlson JA. The histological assessment of cutaneous vasculitis. Histopathology 2010; 56:3.

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خرید پکیج

Types of cutaneous vasculitis[1]

Types of cutaneous vasculitis^[1]