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Effect of carboxyhemoglobinemia on oxygen content and delivery

Effect of carboxyhemoglobinemia on oxygen content and delivery
Red curve demonstrates the normal relationship between arterial (A) and venous (V) oxygen content. In general, a difference in arterial and venous oxygen content of 5 mL per 100 mL blood is expected at rest. The green line depicts the effect of a 50 percent decrease in hemoglobin concentration, which decreases arterial (A') and venous (V'1) oxygen content but does not change the partial pressure at which hemoglobin is 50 percent saturated (P50). The blue curve shows the effect of a 50 percent carboxyhemoglobinemia (COHb), which both decreases oxygen carrying capacity (A') and impairs peripheral unloading of oxygen from hemoglobin under conditions of low oxygen tension (V'2), shifting P50 to the left (P'50). These changes result in a profound reduction in both oxyhemoglobin saturation and delivery of oxygen to peripheral tissues.
Graphic 50058 Version 2.0

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