NCI CTCAE v5.0 serum sickness

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Serum sickness	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Moderate arthralgia; fever, rash, urticaria, antihistamines indicated	Severe arthralgia or arthritis; extensive rash; steroids or intravenous fluids indicated	Life-threatening consequences; pressor or ventilatory support indicated	Death

Serum sickness is characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort, and dyspnea.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 117356 Version 1.0

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NCI CTCAE v5.0 serum sickness