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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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CLC-5 in proximal tubular cells and trafficking of endosomal membranes

CLC-5 in proximal tubular cells and trafficking of endosomal membranes
  • CLC-5 in proximal tubular cells, and trafficking of endosomal membranes. In proximal tubular epithelial cells, CLC-5 is expressed in subapical endosomes in which the V-type H+-ATPase is responsible for electrogenic transport of protons into the endosomal lumen. Filtered proteins bind to receptors such as megalin at the luminal surface of the cell, from which endosomes bud off. Acidification of the endosomal lumen is required for proteins to be freed from the receptor for subsequent lysosomal degradation and return of small peptides and amino acids to the bloodstream. Megalin and other receptor proteins are recycled back to the apical surface.
  • CLC-5 facilitates endosomal acidification by acting as a Cl/H+ exchanger. In the presence of an active H+-ATPase (left panel), the proton gradient would drive exit of H+ coupled with entry of Cl, and this would effectively dissipate the interior positive charge. In the nascent endosome (right panel), an initially high luminal Cl concentration would drive exit of Cl coupled with entry of H+ and thereby achieve acidification in the absence of a proton pump, assuming a mechanism to shunt the inside-positive charge generated by the antiporter.
Graphic 107505 Version 1.0

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