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Lactic acid, citric acid, and potassium bitartrate non-hormonal prescription vaginal pH modulator (VPM) gel for the prevention of pregnancy
Shanna Su & Kathleen L Vincent
doi : 10.1080/17512433.2022.2100347
Expert Review of Clinical Pharmacology, Volume 15, Issue 6 (2022)
A non-hormonal prescription vaginal pH modulator (VPM) gel (Phexxi®), with active ingredients lactic acid, citric acid and potassium bitartrate, has recently been approved for prevention of pregnancy in the United States. The objective of this review is to compile the evidence available from published preclinical and clinical trials to support its use.
A profile of delafloxacin in the treatment of adults with community-acquired bacterial pneumonia
Silvia G?mez-Zorrilla, Elena Sendra & Juan P. Horcajada
doi : 10.1080/17512433.2022.2100346
Community-acquired bacterial pneumonia (CABP) is the most common infectious cause of hospital admission in adults, and poses a significant clinical and economic burden. At the same time, antimicrobial resistance is increasing worldwide with only a few new antibiotics developed in recent years.
Predicting drug response and toxicity in metastatic colorectal cancer: the role of germline markers
Alessia Bignucolo, Lucia Scarabel, Giuseppe Toffoli, Erika Cecchin & Elena De Mattia
doi : 10.1080/17512433.2022.2101447
Despite the introduction of targeted agents leading to therapeutic advances, clinical management of patients with metastatic colorectal cancer (mCRC) is still challenged by significant interindividual variability in treatment outcomes, both in terms of toxicity and therapy efficacy. The study of germline genetic variants could help to personalize and optimize therapeutic approaches in mCRC.
Genetic markers of drug hypersensitivity in pediatrics: current state and promise
Abdelbaset A. Elzagallaai & Michael J. Rieder
doi : 10.1080/17512433.2022.2100345
Drug hypersensitivity reactions (DHRs) represent a great challenge to clinicians due to their unpredictability and severity, notably being potentially fatal. Genetic markers for DHRs have been emerging as potential valuable clinical tools for prediction and diagnosis of DHRs. Dedicated pediatric studies in this field are scarce and many published studies lack key data in this regard.
Ribosomopathies and cancer: pharmacological implications
Gazmend Temaj, Sarmistha Saha, Shpend Dragusha, Valon Ejupi, Brigitta Buttari, Elisabetta Profumo, Lule Beqa & Luciano Saso
doi : 10.1080/17512433.2022.2098110
The ribosome is a ribonucleoprotein organelle responsible for protein synthesis, and its biogenesis is a highly coordinated process that involves many macromolecular components. Any acquired or inherited impairment in ribosome biogenesis or ribosomopathies is associated with the development of different cancers and rare genetic diseases. Interference with multiple steps of protein synthesis has been shown to promote tumor cell death.
Evogliptin for the treatment option for type 2 diabetes: an update of the literature
Ping Zou, Mingxing Guo & Jingbo Hu
doi : 10.1080/17512433.2022.2100348
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been the most widely used for type 2 diabetes (T2D) available worldwide since 2006. DPP-4 inhibitors exert their effects by inhibiting dipeptidyl peptidase-4 to increase the concentration of endogenous incretin hormones (incretin hormone analogues and incretin potentiators) and promote insulin secretion, thereby acting as a glucose regulator.
Favipiravir-based treatment for outcomes of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Shao-Huan Lan, Chih-Cheng Lai, Shen-Peng Chang, Li-Chin Lu, Shun-Hsing Hung & Wei-Ting Lin
doi : 10.1080/17512433.2022.2078701
This meta-analysis of randomized controlled trials (RCTs) investigated the clinical efficacy and safety of favipiravir for patients with mild-to-critical COVID-19.
Efficacy and safety of insulin detemir versus glargine in patients with diabetes: a systematic review and meta-analysis
Soheila Rezaei, Ali Taheri, Saeed Taheri, Sara Kasirzadeh, Behzad Fatemi & Mende M Sorato
doi : 10.1080/17512433.2022.2078700
Performing an updated meta-analysis to compare the safety and efficacy of insulin glargine and insulin detemir in adults with type 1 and type 2 diabetes.
Early-life exposure to antibiotics and subsequent development of atopic dermatitis
Anna Cantarutti, Claudio Barbiellini Amidei, Andrea Stella Bonaugurio, Paola Rescigno & Cristina Canova
doi : 10.1080/17512433.2022.2092471
Antibiotic exposure may be associated with atopic dermatitis (AD). We assessed the risk of developing AD among children early exposed to antibiotics.
The impact of the COVID-19 pandemic lockdown measures on the prescribing trends and utilization of opioids in the English primary care setting: segmented-liner regression analysis
Oula Nawaf Sindi, Faisal Salman Alshaikh, Brian Godman & Amanj Kurdi
doi : 10.1080/17512433.2022.2093715
The COVID-19 lockdown has resulted in limited access to most of the conventional chronic pain management services. Subsequently, changes in opioids’ utilization could be expected. This study assessed the impact of the first COVID-19 lockdown on opioid utilization using aggregated-level, community dispensing dataset covering the whole English population.
